Pathophysiology of clozapine induced sialorrhea and current treatmant choices
Sema Yeşilyurt, İmer Aras, Kürşat Altınbaş, Murat İlhan Atagün, Erhan Kurt
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Article No: 8   Article Type :  Review
Clozapine has been used for approximately 40 years and it is still the gold standard for treatment resistant schizophrenia even though it may cause considerable side effects. One of the common side effects during the treatment with clozapine is sialorrhea. Although clozapine has anticholinergic side effects, pathogenesis of sialorrhea is still unclear. Despite sialorrhea is quite common and might influence quality of life, treatment choices and their efficacy for this side effect is limited. Thus, in this article, pathophysiology and treatment of clozapin induced sialorrhea is reviewed.
Keywords : Clozapine, sialorrhea, pathophysiology, treatment choices
Dusunen Adam The Journal of Psychiatry and Neurological Sciences 2010;23:275-281
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